Currently, the neuroprotectant and memory-enhancing agent for menopausal women with metabolic syndrome is required. Based\non the advantages of polyphenolics on numerous changes observed in menopause with metabolic syndrome and the encapsulation\nmethod, we hypothesized that microencapsulated mulberry fruit extract (MME) could protect brain damage and improve memory\nimpairment in an animal model of menopause with metabolic syndrome. To test this hypothesis, MME at doses of 10, 50, and\n250 mg/kg was given to female Wistar rats which were induced experimental menopause with metabolic syndrome by bilateral\novariectomy (OVX) and fed with high-carbohydrate high-fat (HCHF) diet for 8 weeks. Spatial memory together with neuron\ndensity, oxidative stress status, acetylcholinesterase, and phosphorylation of Erk in the hippocampus was assessed at the end of\nthe study. It was found that MME decreased memory impairment, oxidative stress status, and AChE activity but increased\nneuron density and Erk phosphorylation in the hippocampus. Therefore, the neuroprotective and memory-enhancing effects of\nMME might partly involve the enhanced cholinergic function and Erk phosphorylation but decreased oxidative stress status in\nhippocampus. Therefore, MME is the potential novel neuroprotectant and memory-enhancing agent for menopause with\nmetabolic syndrome. However, further research especially clinical trial is still necessary.
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