The presence of gamma-oryzanol in rice bran oil can be 10â??20-fold higher than tocopherol\nand tocotrienol. Gamma-oryzanol has various pharmacological properties. The objective of this\nstudy was to evaluate the effectiveness of rice bran extract as a gastroprotective in reducing lesions\nin ethanol-induced acute gastric ulcer models in rat, using the ionic liquid-microwave-assisted\nextraction (IL-MAE) method. Rice bran extract was obtained using the IL-MAE method with ionic\nliquid (IL), 1-butyl-3-methylimidazolium tetrafluoroborate [BMIM]BF4 (concentration 0.7 M), and a\nratio of solid/liquid of 15 g/mL, 15 min extraction time, and 10% microwave power. The rats were\npretreated with rice bran extract at different doses (100, 200, and 400 mg/kg body weight; BW) for\nseven days and subsequently exposed to acute gastric lesions induced by 80% ethanol. Omeprazole\n(36 mg/kg BW) was used as a standard anti-ulcer drug. The ulcer index, gastric juice acidity, and\nmucus levels were measured to assess the degree of gastroprotection. The results showed that the oral\nadministration of rice bran extract at a dose of 400 mg/kg BW significantly inhibited the development\nof ulcer formation by 66.75% and reduced gastric acid levels. Moreover, gamma oryzanol and\nomeprazole protected the gastric mucosa from ethanol-induced gastric lesions by increasing the level\nof gastric mucus. Rice bran extract is effective as a gastroprotective therapy sourced from natural\ningredients in treating the incidence of gastric ulcers. Most likely, this is related to gamma oryzanol\nas a bioactive compound contained in rice bran (Oryza sativa L.).
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