Cadmium (Cd) is a toxic heavy metal occurring in the environment as an industrial\npollutant. The systematic accumulation of Cd in the human body may lead to major health problems.\nQuercetin (QE) is a natural flavonoid widely distributed in plants and is a part of human diet.\nMany studies have demonstrated the multiple benefits of QE to humans in protecting cells of our\nbodies. The aim of this study was to investigate the effect of QE and Cd on the proliferation of\nastrocytoma 1321N1 cells. Results indicated that the simultaneous exposure of the cells to 200 .. QE and 16 .. Cd significantly reduced cell viability to 6.9 ± 1.6% with respect to vehicle-treated\ncells. Other experiments of QE pre-treatment followed by the exposure to Cd alone or with QE\nindicated significant but decreased ability of QE or Cd to reduce proliferation of the cells compared\nto their co-incubation. Our study suggested a synergetic anti-proliferative interaction of Cd and QE\nin malignantly transformed cells. This adds new information regarding the biological effects of QE.
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