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Inventi Impact: Animal Models & Cell Assays

Articles

  • Inventi:pac/31850/20
    Role of HMGB1 in an Animal Model of Vascular Cognitive Impairment Induced by Chronic Cerebral Hypoperfusion
    Research 2020 : July - September
    Amelia Nur Vidyanti, Jia-Yu Hsieh, Kun-Ju Lin, Yao-Ching Fang, Ismail Setyopranoto, Chaur-Jong Hu

    Abstract: The pathophysiology of vascular cognitive impairment (VCI) is associated with chronic\ncerebral hypoperfusion (CCH). Increased high-mobility group box protein 1 (HMGB1), a nonhistone\nprotein involved in injury and inflammation, has been established in the acute phase of CCH. However,\nthe role of HMGB1 in the chronic phase of CCH remains unclear. We developed a novel animal\nmodel of CCH with a modified bilateral common carotid artery occlusion (BCCAO) in C57BL/6\nmice. Cerebral blood flow (CBF) reduction, the expression of HMGB1 and its proinflammatory..............

    How to Cite this Article
    Attribution/ CC Compliant Citation: Vidyanti, Amelia Nur, et al. \"Role of HMGB1 in an Animal Model of Vascular Cognitive Impairment Induced by Chronic Cerebral Hypoperfusion.\" International Journal of Molecular Sciences 21.6 (2020): 2176.\nhttps://doi: 10.3390/ijms21062176\nhttp://creativecommons.org/licenses/by/4.0/\n\nSome formatting elements, header, footer, logos, dates and pagination were modified while adapting this article.
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