H1 Antihistamines are used widely in the treatment of allergic disorders and are most effective in relieving the symptoms of seasonal rhinitis and conjunctivitis. . Certain allergic dermatoses, such as acute urticaria, respond favorably to H1 antagonists, which help to relieve the itch in atopic dermatitis or contact dermatitis. H2 Antihistamines (e.g., cimetidine and ranitidine) are used primarily to inhibit gastric acid secretion in the treatment of GI disorders. H2 Antagonists are the drug of choice in treatment of peptic ulceration, Zollinger- Ellison syndrome and gastro-oesophageal reflux disease. H3 antagonists have potential use in improving attention and learning, in stimulating arousal, and as antiepileptic agents. H4 antagonists are promising candidates to treat inflammatory conditions such as allergic rhinitis, asthma, and rheumatoid arthritis. Hence there is need of screening methods for screening of this antagonists. This review presents various models to screen various traditional drugs and modern drugs for histamine (H1, H2, H3, and H4) receptor antagonistic activity. This brings a compilation make easy to go through various models at same time and make it easy to screen the drugs. It reveals principle, apparatus and procedure of these models.
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