Pioglitazone is a thiazolidinedione antidiabetic agent that depends on the presence of insulin for its action. The drug is having the pKa 4.9, so it is well absorbed from the stomach. The drug is having short biological half life and suitable for formulating floating microcapsules. In the present work, the effect of various cross linking agents on drug entrapment efficiency & in vitro release of pioglitazone was studied. Various salts like Cacl2, Bacl2 and Alcl3 were chosen for the study. Formulated microcapsules were evaluated for size, shape, flow properties, wall thickness, drug content, % drug entrapped and in-vitro drug release. The microcapsules formulated using 50 ml of 10% w/v calcium chloride with curing time 60 min yielded the drug release up to 12 hrs and entrapment efficiency 93%.
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