When a new oral dosage form is developed, its dissolution behavior must be quantitatively analyzed. Dissolution analysis involves\na comparison of the dissolution profiles and the application of mathematical models to describe the drug release pattern. This\nreport aims to assess the application of the DDSolver, an Excel add-in software package, which is designed to analyze data obtained\nfrom dissolution experiments. The data used in this report were chosen from two dissolution studies. The results of the DDSolver\nanalysis were compared with those obtained using an Excel worksheet. The comparisons among three different products obtained\nsimilarity factors (????2) of 23.21, 46.66, and 17.91 using both DDSolver and the Excel worksheet. The results differed when DDSolver\nand Excel were used to calculate the release exponent ââ?¬Å?????ââ?¬Â in the Korsmeyer-Peppasmodel. Performing routine quantitative analysis\nproved to be much easier using the DDSolver program than an Excel spreadsheet. The use of the DDSolver program reduced the\ncalculation time and has the potential to omit calculation errors, thus making this software package a convenient tool for dissolution\ncomparison.
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