Oralmucosa is an attractive region for the local and systemic application ofmany drugs. Oralmucoadhesive films are preferred for\ntheir prolonged time of residence, the improved bioavailability of the drug they contain, their painless application, their protection\nagainst lesions, and their nonirritating properties. This work was focused on preparation of nonmedicated carmellose-based films\nusing both solvent casting and impregnation methods, respectively. Moreover, a modern approach to evaluation of mucoadhesive\nfilms applying analysis of texture and subsequentmultivariate data analysiswas used. In this experiment, puncture strength strongly\ncorrelated with tensile strength and could be used to obtain necessary information about the mechanical film characteristics\nin films prepared using both methods. Puncture work and tensile work were not correlated in films prepared using the solvent\ncastingmethod, as increasing the amount of glycerol led to an increase in the puncture work in thinner films. All measured texture\nparameters in films prepared by impregnation were significantly smaller compared to films prepared by solvent casting.Moreover,\na relationship between the amount of glycerol and film thickness was observed, and a greater recalculated tensile/puncture strength\nwas needed for an increased thickness in films prepared by impregnation.
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