The major objective of this study was to prepare and evaluate once daily sustained release matrix pellets formulation of levofloxacin by using extrusion-spheronization technique. The sustained release matrix pellets of levofloxacin were prepared by industrially applied extrusion spheronization technique. The different formulations were prepared using EUDRAGIT L and EUDRAGIT S as hydrophilic or hydrophobic matrix polymer MCC PH101 as a spheronization aid. The prepared pellets were evaluated for parameters like flow properties, morphological characteristics, drug content and in-vitro drug release study in pH 6.8 phosphate buffer experimental design technique was used to select optimized formulation releasing drug for 12 hr. The levofloxacin SR matrix pellets composed of EUDRAGIT L 6% and EUDRAGIT S 6% was selected as optimized. The evaluated parameters of optimised batch were found within the limits. Drug release of optimized batch (F6) at 2 hr was found to be less than 15% (15.67% and at 12 hr more than 90% (99.70%). The results from this study showed that combination of EUDRAGIT L and EUDRAGIT S as hydrophilic matrix polymer MCC PH101 as a spheronization aid was effective and useful for sustaining the levofloxacin release. And hence extrusion spheronization technique can be promising approach for the preparation of pellets which assure its applicability for large scale manufacturing.
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