Solubility is the major challenge concern with bioavailability. Poor aqueous solubility affects dissolution rate of drug and ultimately bioavailability. The adsorption of poor soluble drugs using porous carrier is well known technique to improve drug dissolution. The well known mesoporous material SBA-15 is 2D hexagonally ordered mesoporous silica synthesized by using non-ionic triblock co-polymer P-123 and inorganic silica precursor TEOS. Mesoporous silica attracted as drug carrier due to its adjustable and tunable pore size, high adsorption capacity, large surface area (> 900 m2/g) and large pore volume (0.9 cm3/g). The mesoporous materials are characterized by using mercury porosimetry or NO2 adsorption method, Electron microscopy to confirm the morphology of pores, PXRD to study the polymorphic changes of drug by mesoporous materials. Several in-vitro studies showing the mesoporous silica material improved the dissolution behavior of poorly soluble drugs by protecting amorphous drug from external attack or by changing crystalline state to amorphous form. Mesoporous materials provides competent drug delivery platform for poorly water soluble drugs by physiosorption and subsequent pore filling. Recently the first clinical trial of “C-dots” has deemed them safe for humans and cleared easily by the body.
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