To the date, large number of drugs having better efficiency in clinical application but have restricted its use due to poor water solubility. Nanocrystals have the potential to overcome the issue. Drug nanocrystals are crystals with a size in the nanometer range (mean diameter < 100 nm). Tadalafil is a BCS class II drug, which is an impotence agent. It is used for the treatment of erectile dysfunction and is a cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type-5 (PDE-5) which is selective inhibitor. In this present work, a nanocrystals of Tadalafil (TDL) was formulated by precipitation method using probe sonicator. It was formulated using stabilizer poloxamer 188 with DMSO as solvent and at proper dilution of drug solution with water and obtained dried product by freeze-drying. The significant enhancement solubility and dissolution rate was observed. The characterization of formulation done by differential scanning calorimetry (DSC), fourier transform infrared spectroscopy (FTIR), X-Ray powder diffraction (XRPD), scanning electronic microscopy (SEM) and particle size analysis.
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