The objective of the present investigation was to develop and optimize immediate release pellet formulations of poorly soluble drug telmisartan (TLM) by liquid layering technique to enhance the solubility as well as bioavailability with sodium hydroxide as alkalizer and tween 80 as surfactant. In this study, a 32 full factorial design was employed to optimize the formulation of pellets. In order to optimize formulations, the amount of sodium hydroxide and the amount of tween 80, were chosen as independent variables while the cumulative % drug release at 10 minutes and 20 minutes were taken as dependant variables. The prepared pellets were evaluated for the parameters like flow properties, yield of the pellets, moisture content, friability, drug loading efficiency and in-vitro drug release. All the pellets exhibited good flow properties and the drug loading efficiency was also good. The optimized pellet formulation (F10) showed highest percent of drug release 99.84% by the end of 30 minutes. The optimized pellet formulation F10 was subjected to FT-IR, XRD and stability studies. The compatibility between drug and polymers in the drug-loaded pellets was confirmed by FT-IR studies. The pellet formulation was found to be stable under the tested conditions of storage. In vivo bioavailability studies indicated significance difference between TLM coated pellets and pure drug. Based on the results, the present study revealed that the dissolution as well as oral bioavailability of TLM could be improved by preparing immediate release TLM coated pellets.
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