Background: Due to antibiotic treatment of humans and animals, the prevalence of bacterial resistances increases\nworldwide. Especially in livestock farming, large quantities of faeces contaminated with antibiotics pose a risk of the\ncarryover of the active ingredient to the environment. Accordingly, the aim of the present study was the evaluation\nof the benefit of different oral dosage forms (powder, pellets, granula) in pigs concerning the environmental pollution\nof sulfadiazine. Two subtherapeutic dosages were evaluated in powder mixtures to gain information about their\npotential to pollute the pig barn. Furthermore, a new group of pigs was kept in the stable after powder feeding\nof another pig group to determine the possible absorption of environmentally distributed antibiotics.\nPigs were orally treated with three dosage forms. Simultaneously, sedimentation and airborne dust were collected and\nplasma and urine levels were determined.\nResults: All formulations result in comparable plasma and urine levels, but massive differences in environmental\npollution (powder > pellets, granula). Pigs housing in a contaminated barn exhibit traces of sulfadiazine in plasma\nand urine.\nConclusion: Using pharmaceutical formulations like pellets or granula, the environmental pollution of sulfonamides\ncan significantly be diminished due to massive dust reduction during feeding.
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