Osteoarthritis is a disease that attacks human bones especially in older people and usually non-steroidal antiinflammatory\ndrugs are being prescribed for patients with Osteoarthritis. These kinds of drugs usually have low\naqueous solubility, dissolution and bioavailability. In order to maximize their therapeutic effects, these properties\nshould be develped and enhanced. The purpose of this study was to reduce the particle size of ibuprofen by forming\nmicroparticles and thus enhance its dissolution rate. Ibuprofen was encapsulated into a polymer (polyvinylpyrrolidone)\nusing supercritical fluid technology (supercritical CO2\n) to form drug-polymer microparticles. Dissolution rate and\nsurface characteristics of the prepared drug-polymer microparticles were measured using various characterization\ntechniques such as fourier transform infrared spectroscopy (FTIR), ultraviolet spectroscopy (UV), transmission\nelectron microscopy (TEM), scanning electron microscope (SEM), thermogravimetric analysis (TGA) and differential\nscanning calorimetry (DSC). Various drug-polymer formulations were prepared depending on the operating conditions\n(i.e., different temperatures, pressures, flow rates and different drug solution:CO2\n volume ratio). Results from TEM\nimages and FTIR graphs showed that microparticles were successfully prepared. Different conditions gave different\nmorphologies of drug-polymer microparticles as was confirmed using SEM analysis. Finally, dissolution rate of the\ndrug-polymer microparticles in a simulated gastric fluid showed a promising result and better drug release controll\nover extended period of two hours in comparesion with uncapsulated Ibuprofen.
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