Chitosan-based nanogels have been widely applied as drug delivery vehicles. Spray-drying\nof said nanogels allows for the preparation of dry powder nano-embedded microparticles.\nIn this work, chitosan-based nanogels composed of chitosan, alginate, and/or sodium tri-penta\nphosphate were investigated, particularly with respect to the impact of composition on the resulting\nphysicochemical properties. Different compositions were obtained as nanogels with sizes ranging\nfrom 203 to 561 nm. The addition of alginate and exclusion of sodium tri-penta phosphate led to an\nincrease in nanogel size. The nanogels were subsequently spray-dried to form nano-embedded\nmicroparticles with trehalose or mannitol as matrix excipient. The microparticles of different\ncomposition were mostly spherical with a smooth surface and a mass median aerodynamic diameter\nof 6ââ?¬â??10 Ã?¼m. Superior redispersibility was observed for microparticles containing amorphous trehalose.\nThis study demonstrates the potential of nano-embedded microparticles for stabilization and delivery\nof nanogel-based delivery systems.
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