The objective of this study was to formulate and prepare gliclazide capsule by solid dispersion method using different\nsurfactants and their in vitro evaluation. Solubilising capacity of polyethylene glycol (PEG 6000, PEG 20000) and\npolyvinylpyrrolidone (PVP K 30) was determined at 2% concentration where gliclazide was used as a model drug and water\nwas used as control for comparison. Results showed that PVP K 30 exhibited maximum solubilising capacity. Fusion method\nof solid dispersion was adopted for preparation of capsules using PEG 6000 & PEG 20000 in different ratios. Although\nthese agents are claimed to be good surfactants but our results showed that, the highest cumulative drug release was 1.81\n% for gliclazide and PEG 6000 in a ratio of 1:6. The flow property of capsule granules was determined by angle of repose.\nThe capsules were also subjected to weight uniformity test, disintegration test and moisture permeation test and the chemical\nanalysis of solid dispersions were done by FTIR. From this study, it can be concluded that it is possible to formulate and\nprepare gliclazide capsule by using solid dispersion method.
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