The aim of present work is to determine and analyse the kinetics of drug release from the matrix tablet by employing\nvarious mathematical models. A study was done with Carbidopa and Levodopa ER tablets, 50 mg/200 mg by employing\nwet granulation technique using Hydroxypropyl methylcellulose and Hydroxypropyl cellulose as matrix forming polymer.\nThe in-vitro drug release profile was carried out in 0.1 N HCl (900 mL) using USP dissolution apparatus II (Paddle)\nat 50 rpm at an extended time period of 0.5, 0.75, 1, 1.5, 2, 2.5, 3 and 4 hours. The drug release data was obtained,\nquantitatively correlated and interpreted with various mathematical models viz. Zero order model, first order model,\nHiguchi model, Hixson-Crowell model and Korsmeyer-Peppas model and evaluated to understand the kinetics of drug\nrelease. The criterion for the most suitable model was based on the high degree of coefficient of correlation of drug\nrelease profile of Carbidopa Levodopa ER Tablet. Hence, finally concluded as the drug release pattern of Carbidopa\nLevodopa ER Tablets, 50 mg/200 mg was best fitted with Higuchi square root model and follows Higuchi drug release\nkinetics which is diffusion controlled.
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