The prime objective of the present study was to check the increase in solubility and improving bioavailability of ranolazine drug. It is an antianginal and anti-ischemic drug poorly soluble in aqueous media. As the bioavailability and pharmacological response of the drug is greatly influenced by solubility. Present study investigates the effect of nanocrystals of ranolazine on solubility and to increase in bioavailability. Nanocrystals of the ranolazine were prepared by using antisolvent precipitation technique using polymer like microcrystalline cellulose (MCC), the prepared formulations were characterized by fourier transform infrared spectroscopy, x-ray diffraction study and scanning electron microscopy. Solubility study was performed to check the enhanced properties of nanocrystals of ranolazine. It was observed that, ranolazine nanocrystals exhibited significantly faster solubility compared with conventional from of a drug. The optimized batch was NC7 and ratio of ranolazine drug nanocrystals found to be 1:1 at 1500 rpm. It was found that, formulation of nanocrystals of ranolazine show increase in drug solubility and bioavailability.
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