Dysphagia is common problem among all age groups, especially for geriatric and paediatric patients. Oro-dispersible tablets (ODT) are a novel dosage form that overcome the problems of dysphagia and provides a quick onset of action. The objective of the current study was to develop and evaluate orodispersible tablets of isradipine by using sublimation technique. Orodispersible tablets of isradipine were prepared by direct compression method using different concentrations of mannitol, menthol and camphor. This technique is used to increase the porosity of the tablets in which menthol and camphor were used as subliming agents which in turn forms the porous structure on the surface of tablets after sublimation. Isradipine is an antihypertensive drug used for calcium channel blocker. It is a BCS class III drug. Hence an orally disintegrating tablet formulation of acyclovir was prepared by direct compression, which was taken as the model drug for the study. The formulated tablets were evaluated for different parameters like hardness, friability and in-vitro in-vivo disintegration time along with other physical parameters. The tablets were also evaluated for drug release for 30 minutes in 0.1 N HCl using USP Type II (Paddle Method) dissolution apparatus. The in-vitro drug release study revealed that menthol and camphor (1:1) at a concentration of 10 % (Batch–F5) of the total weight of the tablet offer fast release of isradipine within 10 minutes. These tablets also dissolved within 20-25 seconds in saliva with pleasant taste and smooth mouth feel. It was concluded that oral disintegrating isradipine tablets could be prepared by direct compression using sublimation method.
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