Different from traditional solid dispersion (SD) for improving the dissolution rates of poorly water-soluble drugs, the\nupgraded 4th SD was developed to furnish a drug sustained-release profile. In this work, two different kinds of 4th SDs\nwere fabricated using two electrospinning processes. One is a ternary SD (nanofibers F2) that consisted of ethyl cellulose\n(EC), polyethylene glycol 1000 (PEG), and tamoxifen citrate (TAM) from a modified coaxial process, and the other is a\nbinary SD (nanofibers F1) which is comprised of EC and TAM from a single-fluid blending process. Scanning electronic\nmicroscopic observations demonstrated that F2 (330 �± 50 nm) showed a better quality than F1 (870 �± 230 nm) in terms of\nsize and size distribution although both of them had a smooth surface morphology and a cross section. X-ray diffraction\npatterns verified that both SDs were amorphous nanocomposites owing to the favorable secondary interactions among these\ncomponents, as suggested from the results of FTIR. In vitro dissolution experiments indicated that F2 could furnish an improved\ndrug sustained-release characteristics compared to F1, exhausting all the contained TAM and having weaker leveling-off late\nrelease. The molecular behaviors of drug sustained-release from the binary 4th SD were suggested. The protocols reported\nhere paved an alternative way for developing novel functional nanomaterials for effective delivery of poorly water-soluble\ndrugs.
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