Solubility parameter-dependent drug releasing property is essential in practical drug\ndelivery systems (DDS), and how to combine magnetic nanoparticles(NPs) and suitable polymer\ncoating towards DDS is always a crucial and valuable challenge in biomedical application. Herein,\na controllable drug delivery model with a surface having a chemically tunable solubility parameter is\npresented using hollow magnetite/polyacrylic acid (Fe3O4/PAA) nanocomposites as nanocarrier\ntowards DDS. This composite is prepared by simply coating the modified hollow Fe3O4 with PAA.\nThe coating amount of PAA onto the surface of Fe3O4 (measured by TGA) is about 40% (w/w). Then,\nRhodamine 6G (R6G) is selected as model drug in drug delivery experiment. The efficiency of drug\nloading and drug release of these Fe3O4/PAA nanocarriers are evaluated under various temperature,\nsolvent and pH values. As a result, the best drug releasing rate was achieved as 93.0% in pH = 7.4\nPBS solution after 14 h. The releasing efficiency is 86.5% in acidic condition, while a lower releasing\nrate (30.0%) is obtained in aqueous solution, as different forms (polyacrylic acid and polyacrylate) of\nPAA present different solubility parameters, causing different salt and acid effects in various solvents,\nswelling property of PAA, and binding force between PAA and R6G. Therefore, by changing the\nsolubility parameter of coating polymers, the drug delivery properties could be effectively tuned.\nThese findings prove that the DDS based on magnetic particle cores and polymer encapsulation could\nefficiently regulate the drug delivery properties by tuning surface solubility parameter in potential\ncancer targeting and therapy.
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