Pain is inadequately relieved by escalating doses of a strong opioid analgesic such as\nmorphine in up to 25% of patients with cancer-related severe pain complicated by a neuropathic\n(nerve damage) component. Hence, there is an unmet medical need for research on novel painkiller\nstrategies. In the present work, we used supercritical fluid polymer encapsulation to develop\nsustained-release poly(lactic-co-glycolic acid) (PLGA) biodegradable microparticles containing the\nanalgesic adjuvant drug ketamine, for injection by the intrathecal route. Using this approach with a\nrange of PLGA co-polymers, drug loading was in the range 10â??60%, with encapsulation efficiency\n(EE) of 60â??100%. Particles were mainly in the size rangeâ?¦â?¦â?¦â?¦â?¦
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