Microparticulated drug delivery systems have been used as promising encapsulation\nsystems for protecting drugs for in vitro and in vivo applications, enhancing its stability, providing an\nincreased surface to volume ratio, reducing adverse effects, and hence an improvement in\nbioavailability. Among the studied microparticles, there is a rising interest in the research of\nalginate microparticles for pharmaceutical and biomedical fields confirming its potential to be used\nas an effective matrix for drug and cell delivery. Moreover, calcium alginate has been one of the\nmost extensively forming microparticles in the presence of divalent cations providing prolonged\ndrug release and suitable mucoadhesive properties. Regarding the above mentioned, in this research\nwork, we intended to produce Ca-alginate micro-vehicles through electrospraying, presenting high\nencapsulation efficiency (EE%), reduced protein release across the time, reduced swelling effect,\nand high sphericity coefficient. To quickly achieve these characteristics and to perform an optimal\ncombination among the percentage of alginate and CaCl2, design of Experiments was applied.\nThe obtained model presented to be statistically significant (p-value < 0.05), with a coefficient\nof determination of 0.9207, 0.9197, 0.9499, and 0.9637 for each output (EE%, release, swelling,\nand sphericity, respectively). Moreover, the optimal point (4% of alginate and 6.6% of CaCl2) was\nsuccessfully validated.
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