Dissolution and disintegration of solid dosage forms such as multiple-layer tablet with\ndifferent active ingredients depend on formulation and properties used in the formulations, and it\nmay sometimes result in counterintuitive release kinetics. In this manuscript, we investigate the\nbehavior of combined acetylsalicylic acid and mefenamic acid bi- and triple-layer formulations.\nWe show that the simulation model with a cellular automata predicted the impact of the inert layer\nbetween the different active ingredients on each drug release and provide a good agreement with the\nexperimental results. Also, it is shown that the analysis based on the Noyesâ??Whitney equation in\ncombination with a cellular automata-supported dissolution and disintegration numerical solutions\nexplain the nature of the unexpected effects. We conclude that the proposed simulation approach\nis valuable to predict the influence of material attributes and process parameters on drug release\nfrom multicomponent and multiple-layer pharmaceutical tablets and to help us develop the drug\nproduct formulation.
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