Glimepiride is having poor water solubility and suffering with dissolution rate limited bioavailability. It belongs to class II category under biopharmaceutical classification and needs improvement of dissolution. Various approaches for improving dissolution rate were reported previously but there is no reports regarding the impact of pharmaceutical factors on the dissolution rate of Glimepiride. The present study is representing the data regarding the effect of various excipients (diluents, superdisintegrants, and lubricants) and method of preparation on the dissolution rate of Glimepiride. Glimepiride tablets composed with the diluent (dicalciumphosphate), super disintegrant (sodium starch glycolate), lubricant (stearic acid) and compressed by employing wet granulation technique produced more drug release among the other formulations and offered the similarity with the marketed formulation.
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