From the view of environmental apprehension, supercritical fluid extraction technology (SFE) exhibits excellent opportunities to accomplish key objectives in the drug delivery sector. Due to increasingly stringent environmental regulations, SFE has gained wide acceptance in recent years as an alternative to conventional solvent extraction for separation of natural compounds in many analytical, herbal and industrial processes. SFE using carbon dioxide (CO2) has been recognized as a green technology. It is a clean and versatile solvent with gas-like diffusivity and liquid-like density in the supercritical phase, which has provided an excellent alternative to the use of chemical solvents. The efficient extraction can be obtained with shorter extraction time, less amount of sample and can be used for extraction of thermo labile compounds. Sophisticated modern technologies allow precise regulation of changes in temperature and pressure, and thus manipulation of solvating property of the Super Critical Fluids, which helps the extraction of natural products of a wide range of polarities.
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