The present study was carried out to develop oral controlled release formulations of aceclofenac employing HPMC, ethyl cellulose and methyl cellulose as release retardant materials. Tablet containing solid dispersions of aceclofenac with polyvinyl pyrolidine (PVP k30) in the ratio of 1:1 prepared by solvent evaporation method used as core material and middle layer material for tablets. Compression coated and layered tablets were prepared with release retardant polymers, in which compatibility studies between the drug and excipients were conducted by infrared spectroscopy. The prepared tablets were characterized and results were compared the compression coated with layered tablets. Release rate was described by zero order, first order, Higuchi and peppas equations. In vitro release data revealed that by increasing the concentration of coating layer by compression coating, decreased the values of K than the layer tablets, results indicated that the release rate of drug was retarded by increasing the concentration polymers, mechanism of drug release exhibits non-Fickian diffusion anomalous transport.
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