The role of chronotherapeutics in hypertension management is based on the recognition that blood pressure does not remain constant throughout the day. Instead, it tends to be higher in the early morning hours and lower in the evening hours. The main objective of the present studies reported here was to investigate whether compression coating could be used to produce tablets providing maximum In-vitro drug release 8 to 10 hours after an evening dose taken at approximately 6:00 pm–7.00 pm. The basic idea behind the dosage form development is to investigate effect of coating design on lag time and drug release from directly compressed time-controlled release tablet. The aim of the present study was to design time controlled tablet of Atenolol, as Chronopharmaceutical drug delivery system by press coating. Formulation design involves coating polymer blend ratio (100:0, 75:25, 50:50, 25:75, 0:100 w/w) of Eudragit L-100: HPMC K-15M which were exploited for their pulsatile drug release ability. Coating materials blend were evaluated for micromeritic properties like flow properties, compressibility index, Hausner’s ratio and also evaluated the tablet for hardness, thickness, friability and weight variation. The obtained results showed the capability of the system in delaying drug release for a programmable period of time to attain drug release after 10hours after an evening dose taken at according to a time-dependent approach.
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