The aim of this study was to develop a user-friendly model for spray drying that can aid in the development of a\r\npharmaceutical product, by shifting from a trial-and-error towards a quality-by-design approach. To achieve this, a spray\r\ndryer model was developed in commercial and open source spreadsheet software. The output of the model was first fitted\r\nto the experimental output of a Bu�¨ chi B-290 spray dryer and subsequently validated. The predicted outlet temperatures of\r\nthe spray dryer model matched the experimental values very well over the entire range of spray dryer settings that were\r\ntested. Finally, the model was applied to produce glassy sugars by spray drying, an often used excipient in formulations of\r\nbiopharmaceuticals. For the production of glassy sugars, the model was extended to predict the relative humidity at the\r\noutlet, which is not measured in the spray dryer by default. This extended model was then successfully used to predict\r\nwhether specific settings were suitable for producing glassy trehalose and inulin by spray drying. In conclusion, a spray\r\ndryer model was developed that is able to predict the output parameters of the spray drying process. The model can aid the\r\ndevelopment of spray dried pharmaceutical products by shifting from a trial-and-error towards a quality-by-design\r\napproach.
Loading....