Pharmacovigilance is the pharmacological science and activities relating to the detection, assessment, understanding and prevention of adverse drug effects or any other drug related problem according to World Helth Organization (WHO). It is concered with the post marketing surveillance of medicines and the use of the information generated for education and effective drug regulation. Spontaneous (voluntary) ADR reporting contributes significantly to successful pharmacovigilance. ADR – databases obtained from these reporting is enormously significant in ascertainment of the benefit-risk ratio of some drugs as well as in singal detection of unsuspected and unusual ADRs previously undetected in initial evaluation of drug. This information may be useful in identifying and minimizing preventable ADRs more efficiently. At the same time proper ADR database contributes a lot in withdrawal of harmful drugs from the market. Under reprting however remains a major draw-back of spontaneous reporting. A reason for under reporting includes lack of knowledge, awareness and training. Good ADR-database can be generated by encouraging the doctors for spontaneous reporting. Hence, every country needs an effectively functioning pharmacovigilance programme and knowledge about the programme in health professional. Pharmacovigilance are highly approached by developed country like USA& UK. In the present rieview we discuss various pharmacovigilance system like Med Watch, Yellow Card, PSUR etc. Here also discuss pharmacpvigilance scenario in India. Pharmacovigilance is also important factor in clinical trial. In upcoming year pharmacovigilance is need based strategies to established safety concern of drugs.
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