Introduction: Moisture permeability and a loose closure system might allow a significant gain of\nmoisture into container and this could lead to significant loss of potency of drug sensitive to moisture\nand as well promoting the growth of microorganisms. Typical examples of the drugs sensitive\nto moisture include Tenofovir Disoproxil Fumarate (TDF). Product claimed to be a ââ?¬Å?Tight containerââ?¬Â\ndoes not make it a tight container until proved practically. A plastic container is tight if ââ?¬Å?not\nmore than one of the 10 tested containers exceeds 100 mg per day per L in moisture permeability.\nObjectives: The goal of this study was to determine rate of moisture permeability of selected High\nDensity Polyethylene plastic bottles for packaging of moisture sensitive medicines in particular\nLamivudine/Tenofovir Disoproxil fumarate tablets. Methodology: The determination of rate of\nmoisture permeability was achieved by assessing closure systems of plastics as per USP 37 <671>\nmethod, while the difference in absorption pattern was achieved by assessing the spectrum obtained\nthrough transmittance by Fourier Transform-Infrared (FT-IR). The plastic bottles were\nrandomly selected from supplier A, B and C. Results: The plastic bottles from supplier A and B had an average moisture permeability of 12.57 and 51.55 mg/day/L with none of the containers exceeding\nmoisture permeability of 100 mg/day/L whereas containers from supplier C had an average\nof 149.95 mg/day/L with seven of the containers exceeding of 100 mg/day/L. Conclusion: Containers\nfrom supplier A and B met the USP specifications hence could be used as primary packaging\nfor moisture sensitive medicines whereas the containers from supplier C did not meet the USP\nspecifications for them to be regarded as ââ?¬Å?Tight Containersââ?¬Â and hence, unsuitable for packaging\nof moisture sensitive medicines.
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