Although physical training remains the primary way of changing and developing appearance, there is a range of substances being used by some to enhance the effects of training. Performance Enhancing Drugs refer to substances that are generally used to enhance muscle growth or to reduce body fat. The expected benefits of using these types of substances range from increasing the size and definition of muscles, reducing water retention and body fat, to increasing physical strength and endurance. Performance enhancement in Olympic and Professional has now become a medical, ethical and legal problem for modern athletes and athletic organizations.The review will provide history of performance enhancement drugs and focus on the most widely used anabolic androgenic steroids, growth hormone, protein hormones, diuretics, beta-2 agonists and other hormones such as insulin and thyroxin. Performance enhancement in Olympic and Professional has now become a medical, ethical and legal problem for modern athletes and athletic organizations.
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