Background: Compared to surgery, radiofrequency ablation(RFA) for colorectal liver metastasis(CRLM) is associated\nwith higher local recurrence(LR) rates. A wide margin (at least 5 mm) is generally recommended to prevent LR, but\nthe optimal method to assess ablation margins is yet to be established. The aim of our study was to evaluate the\nfeasibility and reproducibility of CT-CT co-registration, using MIRADA software, in order to assess ablation margins of\npatients with CRLM.\nMethods: In this retrospective study, pre- and post-ablation contrast-enhanced CT scans of 29 patients, treated with\npercutaneous RFA for a solitary CRLM, were co-registered. Co-registration was performed by two independent\nradiologist, based on venous structures in proximity to the tumor. Feasibility of CT-CT co-registration and inter-observer\nagreement for reproducibility and ablation margins was determined. Furthermore, the minimal ablation margin was\ncompared with the occurrence of LR during follow-up......................
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