Theaimof this study was to develop an inexpensive apparatus for fabricating microspheres, based on chitosan, for 5-fluorouracil (5-\nFU) controlled release. Chitosan microspheres were prepared by precipitationmethod and the effects ofmanufacturing parameters\n(injection and airflow rates) on size distribution microspheres were analyzed by optical and scanning electron microscopy. The\nresults show that the manufacturing parameters, injection and airflow rates, determine the microsphere size distribution. By\nmodulating these parameters, it was possible to produce chitosan microspheres as small as 437 �± 44
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