The aim of this study is to determine favorable process conditions for the coating of placebo tablets. Tablets made of microcrystalline\ncellulose are coated with hydroxypropyl cellulose polymer and Advantiaâ?¢ Prime polymeric mixture film in lab-scale\nfluid-bed environment with a Wurster tube. In order to determine favorable process conditions (concentration, Wurster tube\nposition, inlet air temperature, and atomization pressure), evaluation factors expressing process efficiency were calculated.\nStereomicroscopy analysis provided good results with respect to the coating layer adherence and consistency. Results showed that\nthe increased number of the coating cycles contributes to the desired featureless film morphology, when sufficiently high\ntemperature and pressure are applied, thus resulting in high intra- and intertablet uniformity. Additionally, this paper analyzes the\ncoating process from a mechanistic perspective of the underlying phenomena occurring on a tablet surface. Provided diagrams\ncan help efficiently in detecting proper conditions that will result in coated tablets with strictly defined aimed properties. Process\nand formulation properties synergically result in a preferential occurrence of a deposition mechanism for all experiments\nconducted. Moreover, collision is found as a prevalent impact regime for the coating process studied. Finally, our intention here is\nto correlate hydrodynamic conditions and droplet breakup occurrence with a droplet diameter.
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