Curcumin is a hydrophobic polyphenol compound exhibiting a wide range of biological\nactivities such as anti-inflammatory, anti-bacterial, anti-fungal, anti-carcinogenic, anti-HIV, and\nanti-microbial activity. Recently, electrospraying has been successfully used to produce micro-or\nnano-sized particles for pharmaceutical use. In this work, polyvinylpyrrolidone (PVP) microspheres\ncontaining curcumin were prepared via electrospraying in order to improve the bioavailability of\npoorly-water-soluble curcumin. The influence of five processing parameters namely curcumin/PVP\nratio, tip to collector distance, and electric voltage on physic-chemical properties was investigated.\nThe characterization and aqueous solubility of particles were determined by using scanning electron\nmicroscopy (SEM), Fourier transform infrared spectroscopy (FTIR), and UV-Vis spectrophotometer.\nThe result indicated that the spherical particles with particle size distribution of 164 to 730 nm\nobtained at a curcumin/PVP ratio of 1:30, a polymer solution concentration of 0.4%, electric voltage\nof 10 kV, and a tip-to-collector distance of 15 cm. Moreover, the dissolution of curcumin/PVP particle\ngenerated by electrospraying was higher than that of the original curcumin and pure curcumin\nparticles produced by electrospraying.
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