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Inventi Impact: Chemical Engineering

Articles

  • Inventi:eche/30235/19
    Preparation of Zn^2+- Chelated Carboxymethyl Poly(1-Vinylimidazole) for Intracellular Zn^2+ Delivery
    Research 2020 : January - March
    Akito Endo, Shoichiro Asayama

    Zinc ions (Zn^2+), known to be a novel intracellular second messenger related\nto various biological functions, have been delivered inside cells. For the\nintracellular Zn^2+ delivery, Zn^2+ has been chelated to carboxymethyl poly(1-\nvinylimidazole) (CM-PVIm) by mixing zinc chloride (ZnCl2) or zinc acetate\n(Zn(OAc)2) with CM-PVIm. The resulting Zn^2+-chelated CM-PVIm, that is,\nZn^2+/CM-PVIm complex by mixing ZnCl2 exhibited smaller particle size below\n10 nm and possessed larger amount of Zn^2+ ions, as compared to the\nZn^2+/CM-PVIm by mixing Zn(OAc)2. The both Zn^2+/CM-PVIm complexes\nexhibited no significant cytotoxicity, leading to intracellular Zn^2+ delivery.\nThe Zn^2+/CM-PVIm by mixing ZnCl2 delivered larger amount of intracellular\nZn^2+ ions than that by mixing Zn(OAc)2. These results suggest that the optimal\nZn^2+/CM-PVIm complex is a useful tool for intracellular Zn^2+ delivery\nto control various biological functions.

    How to Cite this Article
    Attribution/ CC Compliant Citation: Endo, A. and Asayama, S. (2019) Preparation of Zn^2+- Chelated Carboxymethyl Poly\n(1-Vinylimidazole) for Intracellular Zn2+ Delivery. Journal of Minerals and Materials Characterization and Engineering, 7,\n213-220.\nhttps://doi.org/10.4236/jmmce.2019.75016\nhttp://creativecommons.org/licenses/by/4.0/\n\nSome formatting elements, header, footer, logos, dates and pagination were modified while adapting this article.
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