Supercritical adsorption coupled with the high adsorption capacity of silica aerogel allows the preparation of a new kind of delivery\r\nsystems of poor water soluble drugs. In order to overcome drawbacks of conventional techniques where the use of liquid solvents\r\ncan cause the fracture of aerogel porous structure, in this work a new adsorption process of drugs from a supercritical mixture is\r\nproposed. Adsorption takes place from a fluid solution of the drug in supercritical CO2 and ethanol as cosolvent. A fixed bed\r\nadsorption plant has been developed to allow fast mixing of fluid phase and effective contact in the adsorption column. The\r\nuse of ethanol as cosolvent allows to overcome the limitation of supercritical adsorption due to low solubility of many drugs in\r\nsupercritical CO2. Adsorption isotherms were measured for one-model substance, nimesulide, at 40�°C, and breakthrough curve\r\nwas experimentally obtained.The drug loading of the drug into silica aerogel was up to 9 wt%.Thedrug composite was characterized\r\nusing scanning electron microscopy, and release kinetics of the adsorbed drug were also evaluated by in vitro dissolution tests. The\r\ndissolution of nimesulide fromloaded aerogel ismuch faster than dissolution of crystalline nimesulide. Around 80% of nimesulide\r\ndissolves from the aerogel within 6 minutes, whereas dissolving 80% of the crystalline drug takes about 90 min.
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