A promising strategy for maintaining a healthy and youthful phenotype during\naging is that of mild stress-induced beneficial hormesis. The basis of hormesis lies in the\nmolecular pathways of stress response, which are essential for the survival of a biological\nsystem by activation of maintenance and repair mechanisms in response to stress.\nModerate physical exercise is the best example of a hormetin that brings about a wide\nrange of health beneficial hormesis by first challenging the system. Similarly, other natural\nand synthetic hormetins can be incorporated in cosmeceutical formulations, and can help\nachieve benefits including maintenance of the skin structure and function. Several\npolyphenols, flavonoids and other components from spices, algae and other sources are\npotential hormetins that may act via hormesis. Stress response pathways that can be\nanalyzed for screening potential hormetins for use in cosmetics and cosmeceuticals include\nheat shock response, autophagy, DNA damage response, sirtuin response, inflammatory\nresponse and oxidative stress response.
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