The nanotechnology field is growing at an unprecedented rate. This is resulting\nin significant benefits in skin care products and formulations. Likewise, imaging\ntechnology is also advancing. The convergence of these fields offers a unique opportunity\nto observe and quantify the interactions of nanoparticles within cosmetic and skin care\nformulations. More importantly, imaging technology holds tremendous promise for\nunderstanding how formulated nanoparticles interact with our skin. Imaging technologies\ncan be broken into two major groups that include those that require invasive sample collection\nand processing (e.g., electron microscopy, mass spectrometry, and super-resolution structured\nillumination microscopy) and those that can be used in non-invasive data collection\nsettings. Fluorescence microscopy, confocal microscopy, coherent anti-Stokes Raman\nscattering spectroscopy and optical coherence tomography fall into the latter category and\nare the focus of this review in the context of skin care product and cosmetics testing.\nCosmetic and skin care product testing is most informative when carried out in volunteers.\nThis makes invasive or disruptive analysis techniques unfeasible and supports the use of\nnon-invasive imaging technologies. The combination of non-invasive imaging and\nminimally invasive microbiopsy sampling for combined imaging and molecular data is the\nfuture of skin care product testing.
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