The exposure to ultraviolet radiations (UVR) is the key source of skin sunburn; it may produce harmful entities, reactive oxygen\nspecies (ROS), leading to aging. The skin can be treated and protected from the injurious effects of ROS by using various\npharmaceutical formulations, such as cream. Cream can be loaded with antioxidants to quench ROS leading to photo-protective\neffects. Moreover, modern medicines depend on ethnobotanicals for protection or treatment of human diseases. This review\narticle summarizes various in vivo antioxidant studies on herbal creams loaded with phyto-extracts. These formulations may serve\nas cosmeceuticals to protect skin against injurious effects of UVR. The botanicals studied for dermatologic use in cream form\ninclude Acacia nilotica, Benincasa hispida, Calendula officinalis, Camellia sinensis, Camellia sinensis, Nelumbo nucifera, Capparis\ndecidua, Castanea sativa, Coffea arabica, Crocus sativus, Emblica officinalis Gaertn, Foeniculum vulgare, Hippophae rhamnoides,\nLithospermum erythrorhizon, Malus domestica, Matricaria chamomilla L., Moringa oleifera, Morus alba, Ocimum basilicum, Oryza\nsativa, Polygonum minus, Punica granatum, Silybum marianum, Tagetes erecta Linn., Terminalia chebula, Trigonella foenumgraecum,\nand Vitis vinifera.The observed anti-aging effects of cream formulations could be an outcome of a coordinating action of\nmultiple constituents. Of numerous botanicals, the phenolic acids and flavonoids appear effective against UVR-induced damage;\nhowever the evidence-based studies for their anti-aging effects are still needed.
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