Depigmentation and skin lightening products, which have been in use for ages in\nAsian countries where skin whiteness is a major esthetic criterion, are now also highly valued\nby Western populations, who expose themselves excessively to the sun and develop skin spots as\na consequence. After discussing the various possible mechanisms of depigmentation, the different\nmolecules that can be used as well as the status of the products containing them will now be\npresented. Hydroquinone and derivatives thereof, retinoids, alpha- and beta-hydroxy acids, ascorbic\nacid, divalent ion chelators, kojic acid, azelaic acid, as well as diverse herbal extracts are described in\nterms of their efficacy and safety. Since a genuine effect (without toxic effects) is difficult to obtain,\nprevention by using sunscreen products is always preferable.
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