The history of cosmetics develops in parallel to the history of man, associated with fishing,\nhunting, and superstition in the beginning, and later with medicine and pharmacy. Over the\nages, together with human progress, cosmetics have changed continuously and nowadays the\ncosmetic market is global and highly competitive, where terms such as quality, efficacy and safety are\nessential. Consumers� demands are extremely sophisticated, and thus scientific research and product\ndevelopment have become vital to meet them. Moreover, consumers are aware about environmental\nand sustainability issues, and thus not harming the environment represents a key consideration when\ndeveloping a new cosmetic ingredient. The latest tendencies of cosmetics are based on advanced\nresearch into how to interfere with skin cell aging: research includes the use of biotechnology-derived\ningredients and the analysis of their effects on the biology of the cells, in terms of gene regulation,\nprotein expression and enzymatic activity measures. In this review, we will provide some examples\nof cosmetic active ingredients developed through biotechnological systems, whose activity on the\nskin has been scientifically proved through in vitro and clinical studies.
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