Background: 6-Shogaol is a constituent of ginger that imparts the pungent flavor and a hydrolysis product of\ngingerols. This study aimed to investigate the potential of 6-shogaol as a natural cosmetic raw material by\nexamining its anti-apoptotic, antioxidant, and anti-aging effects in human dermal fibroblasts (HDFs).\nMethods: Cell cycle analysis, ApoAlert caspase-3 colorimetric assay, and qRT-PCR analysis to assess the anti-apoptotic\neffects and qRT-PCR to measure the expression of SOD, CAT, and NRF2 to assess the antioxidant effects of 6-shogaol\nwere performed; dichlorofluorescein diacetate was used to measure reactive oxygen species (ROS). Anti-aging effects\nwere examined using qRT-PCR analysis to measure the expression of COL1A1 and MMP1 as well as using an SA-beta\nGal assay....
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