Hesperidin is one of the most important natural flavonoids, known for its antioxidant,\nanti-inflammatory, anti-mutagenic, and anti-hypertensive properties. Despite its various biological\nactivities, hesperidin is rarely used in the dermo-cosmetic field because of its poor solubility in\nboth water and oil phases that makes difficult formulation, distribution and bioavailability through\nthe skin layers. Moreover, hesperidin is still underestimated in skin care products, and literature\ndata on its stability into a topical formulation are not yet available. In this paper we report the\nsynthesis of five different derivatives of hesperidin and their evaluation in terms of antioxidant,\nantifungal, antiproliferative, and apoptotic effects on human leukemic K562 cells. Preliminary\nantiproliferative effects were considered since hyper-proliferation is involved in several cutaneous\nproblems particularly in the case of photo-exposition and environmental pollution. Esp4 and Esp5\nwere found to be more active in inhibiting K562 cell growth than parent hesperidin. Esp3 exhibited\ndifferent biological properties, i.e., antioxidant activity in the absence of antiproliferative effects.
Loading....