Pickering emulsions are systems composed of two immiscible fluids stabilized by solid\norganic or inorganic particles. Pickering emulsions are particularly useful in cosmetics, where the\nsurfactants are unwanted, as well as in the pharmaceutical field, where transdermal and/or dermal\ndrug delivery is diffcult to achieve and controlled drug release is desired. Here, we studied calcium\ncarbonate particles as stabilizers of Pickering emulsions for topical use. An optimized formulation\nwas obtained using a Quality by Design approach. First, a screening experiment was performed\nto identify the formulation and process critical variables that affect the quality properties of the\nPickering emulsion. The optimization of the production was then studied by establishing the design\nspace. The final formulation was hereinafter investigated regarding the pH, rheological properties,\nand in vitro cytotoxicity assays. The results showed the formulation had a pH compatible with human\nskin and a shear thinning behavior. Moreover, this formulation showed a strong network structure,\nwith a suitable spreadability on the skin, allowing an easy application. The in vitro assays were\nperformed to assess the potential cytotoxicity of the calcium carbonate-stabilized emulsion and the\nparticles themselves, and the results revealed that the formulation did not significantly affect the cell\nviability. In conclusion, the use of calcium carbonate particles as a stabilizer ingredient contributed to\nachieve an eco-friendly Pickering emulsion.
Loading....