Sulfated polysaccharides prepared from marine algae are potential ingredients in\nnutraceutical, pharmaceutical, and cosmeceutical industries. In the present study, the antioxidant,\nanti-melanogenesis, and photoprotective effects of sulfated polysaccharides obtained from\nEcklonia maxima (EMC) were investigated to evaluate their potential in cosmetic. EMC was successfully\nprepared through Celluclast-assisted extraction and ethanol precipitation, and it contained 79.88%\nof sulfated polysaccharides that with 69.37% carbohydrates and 10.51% sulfate. EMC effectively\nsuppressed 2,2-azobis(2-amidinopropane) hydrochloride (AAPH)-induced oxidative stress in vitro in\nVero cells and in vivo in zebrafish. Furthermore, EMC significantly inhibited mushroom tyrosinase\nand reduced melanin synthesis in alpha-melanocyte-stimulating hormone-stimulated B16F10 cells.\nIn addition, EMC remarkably attenuated photodamage induced by UVB irradiation in vitro in\nhuman keratinocytes (HaCaT cells) and in vivo in zebrafish. Furthermore, EMC effectively inhibited\nwrinkle-related enzymes and improved collagen synthesis in UVB-irradiated human dermal fibroblasts\n(HDF cells). These results indicate that EMC possesses strong antioxidant, anti-melanogenesis,\nand photoprotective activities, and suggest that EMC may be an ideal ingredient in the pharmaceutical\nand cosmeceutical industries.
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