Melasma is a common hypermelanotic disorder affecting the facial area which has a considerable psychological impact on the\npatient. Managing melasma is a difficult challenge that requires long-term treatment with a number of topical agents, such as\nrucinol and sophora-alpha. Aims.We aim to compare the combined treatment of skin needling and depigmenting serum with that\nusing depigmenting serum alone in the treatment of melasma, in order to evaluate the use of microneedles as a means to enhance\nthe drug�s transdermal penetration. Methods. Twenty patients were treated with combined skin needling and depigmenting serum\non one side of the face and with depigmenting serum alone on the other side. The outcome was evaluated periodically for up to\ntwo months using theMelasma Area Severity Index score and the Spectrocolorimeter X-Rite 968. Results. The side with combined\ntreatment (skin needling + depigmenting serum) presented a statistically significant reduction in MASI score and luminosity\nindex (L) levels compared to the side treated with depigmenting serum alone, and clinical symptoms were significantly improved.\nConclusions. Our study suggests the potential use of combining skin needling with rucinol and sophora-alpha compounds to\nachieve better results in melasma treatment compared to rucinol and sophora-alpha alone.
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