The phenolic compound phloridzin (phloretin 2-O-glucoside, variously named\r\nphlorizin, phlorrhizin, phlorhizin or phlorizoside) is a prominent member of the chemical\r\nclass of dihydrochalcones, which are phenylpropanoids. Phloridzin is specifically found in\r\napple and apple juice and known for its biological properties. In particular we were\r\nattracted by potential dermo-cosmetic applications. Here we report the synthesis, stability\r\nstudies and antimicrobial activity of compound F2, a new semi-synthetic derivative of\r\nphloridzin. The new derivative was also included in finished formulations to evaluate its\r\nstability with a view to a potential topical use. Stability studies were performed by HPLC;\r\nPCL assay and ORAC tests were used to determine the antioxidant activity. F2 presented\r\nan antioxidant activity very close to that of the parent phloridzin, but, unlike the latter, was\r\nmore stable in formulations. To further explore potential health claims, antifungal activity\r\nof phloridzin and its derivative F2 were determined; the results, however, were rather low;\r\nthe highest value was 31,6% of inhibition reached by F2 on Microsporum canis at the\r\nhighest dose.
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