Silk sericin is a natural macromolecular protein derived from the silkworm, Bombyx mori. It is also a by-product\r\nof silk-making. From previous reports, many cosmeceuticals and other cosmetic products have been developed\r\nwith silk sericin. This study aimed to investigate an anti-aging property of silk sericin by in-vitro characterization\r\nusing fibroblast cell culture model. The results showed that silk sericin can stimulate collagen type I synthesis,\r\nsuppress the regulation of nitrite, which nitrite may induces oxidative stress, and up-regulate the expression of\r\nb-cell lymphoma 2 (bcl-2) to inhibit cell apoptosis, without altering fibroblast growth kinetics or cellular\r\nultrastructure. Sericin anti-aging properties were comparable to vitamin C, except for oxidative stress, where silk\r\nsericin was superior. The results suggested that silk sericin possesses anti-aging properties that could be usefully\r\nincorporated into high-quality cosmetics, cosmeceuticals, and food supplements.
Loading....